/Publications
2026~
1. W.-B. Lu, Y.-S. Huang, J.-C. Wu, L.-W. Chen, I-W. Lin, P.-C. Chen, P.-H. Chen, C.-Y. Huang, T.-T. Tai, S.-H. Huang, S.-H. Wu, F.-S. Wang, H.-W. Chao*, M.-H. Tai*. Irisin Gene Delivery Elicits Sustained Amelioration of Diabetes in Akita Mice via Insulin-Independent Regulation of Hepatic Glucose Metabolism. 2026 Aug., Diabetes. Accepted (* Corresponding)
2. W. Yang, X. Wang, B. Xiao, C. Li, Y. Guo, K. Tang, A. Wang, H.-W. Chao*, Y. Jin*, H. Chen*. Berberine alleviates LPS-induced inflammatory response by targeted activation of NR1D1 in bovine endometrial epithelial cells. International Immunopharmacology, 2026 Aug. 15, (13) 116858. (* Corresponding)
3. G. Han, X. Wu, X. Xiao, T. Guo, D. Li, H. Zhang, D. Gao, C. Li, A. Wang, H.-W. Chao*, Y. Jin*, H. Chen*. RhythmInsight: An Interactive Web Platform for Circadian and Diurnal Rhythmic Analysis and Visualization. Journal of Biological Rhythms, 2026 May 05, 07487304261437377. (* Corresponding)
2021~2025
1. H.-W. Chao, Y.-M.-J. Lin, C.-S. Wu, Biomarker-Based Precision Prediction of Immunotherapy Response in Hepatocellular Carcinoma. Diagnostics, 2025 Dec. 28, 16 (1), 85 (Field order: 57/332)
2. C.-S. Wu, T.-Y. Lee, H.-W. Chao*. Targeting glypican-3 as a new frontier in liver cancer therapy. World journal of hepatology, 2025 Sep. 27, 7 (9), 107671 (Field order: 68/148) (* Corresponding)
3. G. Han, D. Li, H. Zhang, C. Li, L. Yang, T. Ma, X. Wang, B. Ma, X. Wu, Y. Tao, Z. Wang, A. Wang, H.-W. Chao*, Y. Jin* & H. Chen*. A transcriptomic Dataset of Liver tissues from Global and Liver Specific Bmal1 Knockout Mice. Scientific Data. (2025) Feb. 13;18 (6): 4822-4839. doi: 10.1038/s41597-025-04545-4 (* corresponding authors)
4. Y.-W. Chao¥, Y.-L. Lee¥, C.-S. Tseng¥, L. Wang, K.-C. Hsia, H. Chen, J.-M. Fustin, S. Azeem, T.-T. Chang, Y.-P. Hsueh*, Y.-S. Huang*, H.-W. Chao¥*, Improved CaP-nanoparticles transforming nucleic acid and protein delivery to neural primary culture and stem cells. ACS NANO, (2024) Feb 13;18(6):4822-4839. doi: 10.1021/acsnano.3c09608, (* corresponding authors; ¥ Equal contribution)
5. W. Yang, M. Jin; Y. Wang, H. Zhao, X. Wang, Y. Guo; C. Li, B. Xiao, H. Zhang, K. Fouzia, A. Wang, H.-W. Chao*, Y. Jin*, H. Chen*. NR1D1 activation alleviates inflammatory response through inhibition of IL-6 expression in bovine endometrial epithelial cells. International Journal of Biological Macromolecules, (2024) Nov. 16, 137642, doi.org/10.1016/j.ijbiomac.2024.137642, (* corresponding authors)
6. H. Zhao, G. Han, Z. Jiang, D. Gao, H. Zhang, L. Yang, T. Ma, L. Gao, A. Wang, Q. Li, H.-W. Chao*, Y. Jin*, H. Chen*, Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates. Biochemical and Biophysical Research Communications, (2024) Feb. (696), doi: 10.1016/j.bbrc.2023.149422, (* corresponding authors)
7. C.-S. Tseng, Y.-W. Chao, Y.-H. Liu, Y.-S. Huang*, H.-W. Chao*, Dysregulated proteostasis network in neuronal diseases. Frontiers in Cell and Developmental Biology, (2023) Invited Review, doi: org/10.3389/fcell.2023.1075215, (* corresponding authors),
8. C.-S. Wu¥, W.-H. Lu¥, M.-C. Hung*, Y.-S. Huang*, and H.-W. Chao¥*, From polyploidy to polyploidy reversal, its role in the normal and disease states. Trends in Genetics, (2022), Invited Forum article, Online ahead of print. doi: 10.1016/j.tig.2022.05.007, (* corresponding authors; ¥ Equal contribution),
9. C.-W. Lin, D. Septyaningtrias¥, H.-W. Chao¥, M. Kond, K. Atarashi, K. Takeshita, K. Tamada, J. Nomura, Y. Sasagawa, K. Tanaka, I. Nikaido, K. Honda, T. J. McHugh and T. Takumi, A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in an idiopathic autism mouse model. Molecular Psychiatry, (2022), doi: 10.1038/s41380-022-01566-y, (¥ Equal contribution)
10. H.-W. Chao¥, W.-H. Lu¥, P.-Y. Lin, S.-H. Lin, T.-H. Liu, H.-W. Chen, and Y.-S. Huang, CPEB3 dowregulated Nr3c1 mRNA translation confers resilience to developing posttraumatic stress disorder-like behavior in fear-conditioned mice. Neuropsychopharmacology, (2021), doi: 10.1038/s41386-021-01017-2, (¥, equal contribution),
11. H. Lin¥, Y.-S¥. Huang, J.-M. Fustin, M. Doi, H. Chen, H.-H. Lai, S.-H. Lin, Y.-L. Lee, P.-C. King, H.-S. Hou, H.-W. Chen, P.-Y. Young, H.-W. Chao¥*, Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver. Nature Communications, (2021), Jan 28;12(1):645. doi: 10.1038/s41467-020-20572-8. (* corresponding authors; ¥ Equal contribution)
* Featured in a Nature Communications Editors’ Highlights webpage “Cancer”.
* Commented by Nature Communications, entitled "Ploidy dynamics increase the risk of liver cancer initiation".
* Recommended by Faculty Opinions as Very Good article.
12. Y.Xiao, L. Zhao, W. Li, X. Wang, T. Ma, L. Yang, L. Gao, C. Li, M. Zhang, D. Yang, J. Zhang, H. Jiang, H. Zhao, Y. Wang, H.‐W. Chao, A. Wang, Y. Jin, H. Chen, Circadian clock gene BMAL1 controls testosterone production by regulating steroidogenesis‐related gene transcription in goat Leydig cells. Journal of Cellular Physiology, (2021), doi:10.1002/jcp.30334
2016~2020
1. Y.-S. Huang, K.-C. Lu, H.-W. Chao, A. Chen, T.-K. Chao, C.-Y. Guo, H.-Y. Hsieh, H.-M. Shih, H.-K. Sytwu, C.-C. Wu, The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells. Journal of Cellular Physiology, (2020), doi:10.1002/jcp.29988
2. H.-W. Chao¥, Y.-T.g Lai¥, A. C.-Y. Lai, S.-H. Lin, Y.-J. Chang, Y.-S. Huang, CPEB2-activated PDGFRa mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis. Journal of Biomedical Science, (2020), MS ID: JBMS-D-19-01669R1. (¥, equal contribution)
3. H.-W. Chao, S.-W. Chao, H. Lin, H.-C. Ku, C.-F. Cheng, Homeostasis of glucose and lipid in non-alcoholic fatty liver disease. International Journal of Molecular Sciences, (2019) Jan. 20(2): 298. doi: 10.3390/ijms20020298
4. H.-Y. Liu, C.-Y. Chen, Y.-F. Hung, H.-R. Lin, H.-W. Chao, P.-Y. Shih, C.-N. Chuang, W.-P. Li , T.-N. Huang , Y.-P. Hsueh, RNase A Promotes Proliferation of Neuronal Progenitor Cells via an ERK-Dependent Pathway. Front in Molecular Neuroscience, (2018) Nov. 26; 26(11): 248. doi: 10.3389/fnmol.2018.00428
5. H.-W. Chao, M. Doi, J.-M. Fustin, H. Chen, Y. Maeda, H. Hayashi, R. Tanaka, M. Sugawa, N. Mizukuchi, Y. Yamaguchi, J. Yasunaga, M. Matsuoka, M. Sakai, M. Matsumoto, S. Hamada, H Okamura, Circadian clock regulates hepatic polyploidy by modulating Mkp1-ERk1/2 signalling pathway. Nature Communications, (2017) Dec 21; 8: 2238. doi: 10.1038/s41467-017-02207-7
6. C.-S. Tseng, H.-W. Chao, H.-S. Huang and Y.-S. Huang, Olfactory Experience- and Developmental Stage-Dependent Control of CPEB4 Regulates c-Fos mRNA Translation for Granule Cell Survival. Cell Reports, (2017) Nov 21;21(8): p2264-2276. doi: 10.1016/j.celrep.2017.10.100.
7. M. Doi, I. Murai, S. Kunisue, G. Setsu, N. Uchio, R. Tanaka, S. Kobayashi, H. Shimatani, H. Hayashi, H.-W. Chao, Y. Nakagawa, Y. Hotta, Y. Takahashi, J. Yasunaga, M. Matsuoka, M. Hastings, H. Kiyonari, and H. Okamura, Gpr176 is a Gz-linked orphan G-protein coupled receptor that sets the pace of circadian behavior. Nature Communications, 2016 Feb 17;7:10583. doi: 10.1038/ncomms10583
2005~2015
1. W.-H. Huang¥, H.-W. Chao¥, W.-H. Lu, and Y.-S. Huang, Elevated activation of CaMKIIa in the CPEB3-knockout hippocampus impairs a specific form of NMDAR-dependent synaptic depotentiation. Frontiers in Cellular Neuroscience, (2014) 8: e367 (¥, equal contribution)
2. H.-W. Chao¥, L.-Y Tsai¥, Y.-L. Lu, P.-Y. Lin, W.-H. Huang, H.-J Chou, W.-H. Lu, H.-C. Lin, P.-T. Lee and Y.-S. Huang, Deletion of CPEB3 Enhances Hippocampus-Dependent Memory via Increasing Expressions of PSD95 and NMDA Receptors., Journal of Neuroscience, (2013) 33 (43), p17008-17022.
* Highlighted by cover art of JN, and featured by BrainFacts.org.
3. H.-W. Chao, Y.-T. Lai, Y.-L. Lu, C. Lin, W. Mai and Y.-S. Huang, NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3., Nucleic Acids Research, (2012) 40: p8484-98
4. H.-F. Wang, Y.-T. Shih, C.-Y. Chen, H.-W. Chao, M.-J. Lee, and Y.-P. Hsueh, Valosin-containing protein and neurofibromin interact to regulate dendritic spine density., Journal of Clinical Investigation, (2011) 121: p4820-4837.
* Highlighted by a commentary in the same issue of JCI.
5. H.-W. Chao, C.-J. Hong, T.-N. Huang, Y.-L. Lin, and Y.-P. Hsueh, SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis., Journal of Cell Biology, (2008) 182, p141-155.
* Highlighted by Faculty 1000, THE MUST BE READ ARTICLE.
